|Title||Identified antimicrobial materials in native microorganism in Uleungdo Island.|
- Found compound with new chemical structure which deters cancer metastasis and has antibacterial activity
- Expected to utilize the discovery for research on new agent that deters cancer metastasis and super bacteria
Anti-cancer Agent Research Center (head Ahn Jong-seo, Dr. Jang Jae-hyeok, Dr. Hong Young-soo, Dr. Sohn Sang-geun, etc.) of the Korea Research Institute of Bioscience & Biotechnology (KRIBB, President Chang Kyu-tae) successfully found new microbial metabolites called Ulleungamide A, B, ulleunmycin A, B, and Ulleungoside which have new chemical structure and have anti-cancer and antibacterial activity characteristics that have not known in the natural system from native antinomyctes in Uleungdo soil.
Bioactive materials produced by microorganisms have been used for the development of medicines such as anti-cancer drugs and antibiotics. Those materials have been used as an important starting material for new drug development based on variety of chemical structures. Recently, those materials are put on the spotlight as useful compound for the development of new drug target with identification of new drug candidate activities and analysis on mechanism based on chemical biology becoming active.
Actinomycetes lives in various natural environment including soil and ocean and is able to produce various kinds of bioactive materials including anti-biotics. As such, it is used as important microorganism resources for the development of new drugs.
The most important thing in exploring microorganism origin bioactive materials is to find compound with new chemical structure which has not been found before. It is very important for the development of new drugs which have mechanism differentiated from existing drugs.
In this study, 200 kinds of actinomycetes have been separated using various kinds of microorganism separation method from Uleungdo soil sample which has not been used for research on microorganism origin bioactive material. New bioactive materials were separated from two kinds of Streptomyces sp. KCB13F003, KCB13F030 by conducting exploration utilizing diversification of culture condition, whole genome sequencing analysis, and liquid chromate graphy mass analysis method.
The research team named the newly found bioactive materials after the location where microorganism that produces the compound live such as ulleungamide, ulleunmycin and Ulleungoside.
The bioactivity verification result shows that ulleungamide does not have cytotixicity and antibacterial activity showing the possibility as antibacterial material. Ulleunmycin shows the possibility of anti-cancer agent by deterring the movement and penetration of cancer cells as well as deterring the growth of antibiotics resistant bacteria. In addition, Ulleungoside is found to have diverse bioactivity as it deters the growth of cancer cell.
This research indicated the possibility of utilizing Uleungdo soil as major domestic resources for microorganism origin new compounds by identifying new secondary metabolites through separation of microorganism from Uleungdo soil, which has not been investigated in the previous study.
In addition, ulleungamide among other compounds is found to have new chemical structure which has not been reported, which is meaningful in that in expands the chemical diversity of compounds existing in the natural system.
In addition, it is meaningful in that the the improtance of the utilization of genome information for identifying new microorganism origin secondary metabolites was highlighted by reporting research that applies new secondary metabolite identification method based on genome information, which is not actively used in Korea.
It is urgent to develop treatment for infection with super bacteria, which is resistant to antibiotics and cancer metastasis which is the movement of cancer cell to other parts of human body is regarded as major cause of death from cancer. It is expected that further research on new compound identified in this research will be utilized for the development of new antibiotics and anti-cancer drugs as well as new drug target identification.
Dr. Sohn Sang-geun, the lead author of this study, released the paper for his doctorate degree titled “identification of secondary metabolite from actinomyces in Uleungdo soil based on his research conducted while he was in integrated mater-doctorate degree course at University of Science and Technology (UST).
The research was conducted with the support from KRIBB professional research center project an National Research Council of Science & Technology and was published in Organic Letters (2015) and Journal of Natural Products (2017) which are world’s leading journals for organic chemical and natural chemical area.
The research team has separated and cultivated microorganisms from various environment in Korea including Uleungdo to report new materials which can be used for treatment of various diseases such as Haenamindole (fungus originated from Haaenam sediment), Geumsanol (fungus originated from Geumsan ginseng farm) and Boseongazepine (actinomycetes originated from soil in Boseong green tea farm) which are named after the location where the materials were found to international journals.