|Title||The Key to Resolving Neural Cancer and Neurodegenerative Diseases is to Adjust Calcium|
- Identification of the principle of neural stem cell development by changes in calcium control protein within mitochondria
- Expectation to use it as a new mark for the development of treatment for neural cancer and neurodegenerative diseases in the future
A domestic team of researchers identified the impact of the changes of a certain protein in mitochondria cell on maintaining neural stem cells and cell division by controlling calcium within mitochondria. It is expected to be used as a new mark for development of treatment for cancer, metabolic diseases and neurodegenerative diseases by controlling calcium in mitochondria and homeostasis.
Mitochondria, which is a representative organelle, plays the role as a plant within cell by generating ATP, a major energy source for cells through oxidative phosphorylation process from glucose absorbed from nutrients.
The research team found that Miro protein in mitochondria undergoes phosphorylation by enzyme called Polo kinase moving mitochondria to endoplasmic reticulum promoting the absorption of calcium. In addition, it was found that self-renewal activation of neural stem cells is controlled depending on the calcium concentration of mitochondria.
The Dr.Kyu-Sun Lee, a lead author of this research, said “the outcome of this research is that we found that it is important to control calcium homeostasis of mitochondria for efficient treatment of neural cancer and neurodegenerative diseases”. He added that “the development of new drugs targeting both mitochondria calcium control mechanism through interaction of Polo-Miro protein, which is newly identified and related calcium control elements is expected to contribute significantly to the development of not only treatment for cancers but also treatment for neurodegenerative diseases, inflammable diseases, cardiovascular diseases, and diseases related to muscle aging and aging”.