|Title||Development of Highly-Efficient Drug Screening Technology Using Nanopore|
- Expectation to improve the efficiency of new drug development with screening technology with extremely small amount, ultra sensitivity and no marker
A team of domestic researchers developed a new highly-efficient drug screening technology with extremely small amount, ultra sensitivity and no marker using nanopore based on nano-bio convergence technology. It is expected that the technology contributes significantly to improving efficiency of new drug development by reducing time and cost required for new drug development.
The research was jointly conducted by research team of Director Seung-Wook Chi of the Disease Target Structure Research Center of the Korea Research Institute of Bioscience & Biotechnology (KRIBB) and research team of Professor Ki-Byeom Kim of Department of Materials Science at Seoul National University (corresponding author: Dr. Seung-Wook Chi, Professor Ki-Byeom Kim, lead co-author: Dong-Kyu Kwak in doctor’s course, Hong-Sik Chae in doctor’s course, Dr. Mi-Kyung Lee). The research was supported by promising pioneer project and traditional and natural product based bio synergy research pursued by the Ministry of Science, ICT and Future Planning and the National Research Foundation of Korea. The research was published in online edition of Angewandte Chemie International Edition (IF 11.3) dated on Apr. 1 (Apr. 2, based on Korea standard time), which is world’s renowned journal in chemistry area and PCT patent application was done home and abroad.
The research team used nanopore technology for the purpose of identifying anti-cancer drugs that deters interaction of protein and protein which is the important target for cancer treatment and successfully developed technology that can screen anti-cancer drug that deters protein-protein interaction rapidly with extremely small amount of picomole (1 mole by 1 trillion).
Dr. Seung-Wook Chi said “the research outcome is that we developed the highly-efficient screening platform technology for drug that deters protein-protein interaction through single molecule analysis with no marker, extremely small amount and high sensitivity using nanopore”. He added that “it is expected that this technology contributes significantly to improving efficiency of new drug development by making drug screening process, which used to consume lots of cost and time, low-cost and high-efficiency process during new drug development”.